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2013
Glycosylation of conotoxins.
Marine Drugs. 11(3):623-642, (2013).
Gerwig, G.J., Hocking, H.G., Stöcklin, R., Kamerling, J.P. and Boelens, R.
Position-specific scoring matrix and hidden Markov model complement each other for the prediction of conopeptide superfamilies.
Biochim Biophys Acta. doi:pii: S1570-9639(12):00295-6, (2013).
Koua, D., Laht, S., Kaplinski, L., Stöcklin, R., Remm, M., Favreau, P. and Lisacek, F.
Structure of the O-glycosylated conopeptide CcTx from Conus consors venom.
Chemistry. 19(3):870-879, (2013).
Hocking, H.G., Gerwig, G.J., Dutertre, S., Violette, A., Favreau, P., Stöcklin, R., Kamerling, J.P. and Boelens, R.
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2012
The mitochondrial genome of the venomous cone snail Conus consors.
PlosONE. 7(12)e51528:1-10, (2012).
Brauer, A., Kurz, A., Stockwell, T., Heidler, J., Wittig, I., Kauferstein, S., Mebs, D., Stöcklin, R. and Remm, M.
Conus consors snail venom proteomics proposes functions, pathways and novel families involved in its venomic system.
J. Proteome Res. 11(10):5046-5058, (2012).
Leonardi, A., Biass, D., Kordiš, D., Stöcklin, R., Favreau, P. and Križaj, I.
Spider venom components as drug candidates.
In: Spider Ecophysiology (Nentwig, W. Ed.). Springer Verlag, Heidelberg, Germany. In press, (2012).
Oldrati, V., Bianchi, E. and Stöcklin, R.
Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach.
J. Proteomics. 75(17):5215-5225, (2012).
Violette, A., Biass, D., Dutertre, S., Koua, D., Piquemal, D., Pierrat, F., Stöcklin, R. and Favreau, P.
Molecular phylogeny, classification and evolution of conopeptides.
J. Mol. Evol. 74(5-6):297-309, (2012).
Puillandre, N., Koua, D., Favreau, P., Olivera, B.M. and Stöcklin, R.
ConoDictor: a tool for prediction of conopeptide superfamilies.
Nucleic Acids Res. 40(Web Server issue):W238-41, (2012).
Koua, D., Brauer, A., Laht, S, Kaplinski, L., Favreau, P., Remm, M., Lisacek, F. and Stöcklin, R.
Peak capacity optimisation for high resolution peptide profiling in complex mixtures by liquid chromatography coupled to time-of-flight mass spectrometry: Application to the Conus consors cone snail venom.
J. Chromatogr. A. 1259:187-99, (2012).
Eugster, P.J., Biass, D., Guillarme, D., Favreau, P., Stöcklin, R. and Wolfender, J.L.
A novel mu-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.
Brit. J. Pharmacol. 166(5):1654-68, (2012).
Favreau, P., Benoit, E., Hocking, E., Carlier, L., D’hoedt, D., Leipold, E., Markgraf, D., Schlumberger, S., Cordova, M., Gaertner, H., Paolini-Bertrand, M., Hartley, O., Tytgat, J., Heinemann, S., Bertrand, D., Boelens, R., Stöcklin, R. and Molgo, J.
Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms.
Marine Drugs. 10:258-280, (2012).
Violette, A., Leonardi, A., Piquemal, D., Terrat, Y., Biass, D., Dutertre, S., Noguier, F., Ducancel, F., Stöcklin, R., Križaj, I. and Favreau, P.
Macroevolution of venom apparatus innovations in auger snails (Gastropoda; Conoidea; Terebridae).
Mol. Phylogenet. Evol. 64(1):21-44, (2012).
Castelin, M., Puillandre, N., Kantor, Y.I., Modica, M.V., Terryn, Y., Cruaud, C., Bouchet, P. and Holford, M.
From venoms to drugs: introduction.
Toxicon. Editorial, 59(4):433-433, (2012).
Harvey, A.L. and Stöcklin, R.
Identification and classification of conopeptides using profile Hidden Markov Models.
Biochem. Biophys. Acta 1824(3):488-492, (2012).
Laht, S., Koua, D., Kaplinski, L., Lisacek, F. Stöcklin, R. and Remm, M.
Bioinformatic challenges in DNA metabarcoding.
Mol. Ecol. 21(8):1834-47, (2012).
Coissac, E., Riaz, T. and Puillandre, N.
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2011
Future perspectives of venoms for drug discovery.
Pharmanufacturing: The international peptide review (Nov. 2011):21-24, (2011).
Stöcklin, R. and Vorherr, T.
High resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors.
Toxicon 59(1):34-46, (2011).
Terrat, Y., Biass, D., Dutertre, S., Favreau, P., Remm, M., Stöcklin, R., Piquemal, D. and Ducancel, F.
Venom composition and strategies in spiders: is everything possible?
Advances in Insect Physiology 40:1-86, (2011).
Kuhn-Nentwig, L., Stöcklin, R. and Nentwig, W.
Venomic study on cone snails (Conus spp.) from South Africa.
Toxicon 57(1):28-34, (2011).
Kauferstein, S., Port, C., Kendel, Y., Wunder, C., Nicke, A., Kordis, D., Favreau, P., Koua, D., Stöcklin, R. and Mebs, D.
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2010
Sequencing the genome of Conus consors: preliminary results.
In Advances and new technologies in Toxinology. Barbier J, Benoit E, Marchot P, Mattéi C and Servent D (eds). SFET Editions, Gif sur Yvette, France, Epub on http://www.sfet.asso.fr (ISSN 1760-6004), pp 11-16, (2010).
Stockwell, T., Baden-Tillson, H., Favreau, P., Mebs, D., Ducancel, F. and Stöcklin, R.
CONCO, the cone snail genome project for health.
In Advances and new technologies in Toxinology. Barbier J, Benoit E, Marchot P, Mattéi C and Servent D (eds). SFET Editions, Gif sur Yvette, France, Epub on http://www.sfet.asso.fr (ISSN 1760-6004), pp 17-20, (2010).
Bianchi, E., Favreau, P., Benoit, E., Molgo, J., Ducancel, F., Servent, D., Stockwell, T., Mebs, D., Ménez, R., Miljanich, G. and Stöcklin, R.
New tools to discover active molecules in venoms : from theory to practice.
In Advances and new technologies in Toxinology. Barbier J, Benoit E, Marchot P, Mattéi C and Servent D (eds). SFET Editions, Gif sur Yvette, France, Epub on http://www.sfet.asso.fr (ISSN 1760-6004), pp 55-62, (2010).
Favreau, P., Neveu, E., Maver, M., Stöcklin, R. and Bertrand, D.
Rapid intraspecimen evolution of cone snail venom composition : multiplying pharmacological profiles?
In Advances and new technologies in Toxinology. Barbier J, Benoit E, Marchot P, Mattéi C and Servent D (eds). SFET Editions, Gif sur Yvette, France, Epub on http://www.sfet.asso.fr (ISSN 1760-6004), pp 175-176, (2010)..
Biass, D., Dutertre, S., Favreau, P. and Stöcklin, R.
Venoms - a natural source for mini-protein drugs.
Pharmanufacturing: The international peptide review (Sept. 2010):44-46, (2010).
Stöcklin, R. and Vorherr, T.
Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (Hymenoptera: Megachilidae).
Toxicon 55(1):20-27, (2010).
Stöcklin, R., Favreau, P., Thai, R., Pflugfelder, J., Bulet, P. and Mebs, D.
Dramatic intraspecimen variations within the injected venom of Conus consors: an unsuspected contribution to venom diversity.
Toxicon 55(8):1453-62, (2010).
Dutertre, S., Biass, D., Stöcklin, R. and Favreau, P.
Isolation and characterization of two new Lys49 PLA2s with heparin neutralizing properties from Bothrops moojeni snake venom.
Toxicon 55(6):1080-92, (2010).
Perchuc, A.M., Menin, L., Favreau, P., Buehler, B., Bulet, P., Schöni, R., Wilmer, M., Ernst, B. and Stöcklin, R.
Use of venom peptides to probe ion channel structure and function.
J. Biol. Chem. 285(18):13315-20, (2010).
Dutertre, S. and Lewis, R.J.
Plateletactive substances in the venom of Bothrops moojeni snake-a novel evaluation method using whole blood aggregometry.
Platelets. 21(1):20-8, (2010).
Demler, C., Buehler, B., Menin, L., Stöcklin, R., Wilmer, M., Ernst, B. and Perchuc, A.M.
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2009
Marine snail venoms : use and trends in receptor and channel neuropharmacology.
Curr. Opin. Pharmacol. 9(5):594-601, (2009).
Favreau, P.and Stöcklin, R.
Comparative proteomic study of the venom of the piscivorous cone snail Conus consors.
J. Proteomics 72(2):210-218, (2009).
Biass, D., Dutertre, S., Gerbault, A., Menou, J.-L., Offord, R.E., Favreau, P. and Stöcklin, R.
New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors.
Toxicon 54(3):295-301, (2009).
Kauferstein, S., Kendel, Y., Nicke, A., Coronas, F.I., Possani, L.D., Favreau, P., Krizaj, I., Wunder, C., Kauert, G. and Mebs, D.
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2008
High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry.
Toxicon 51(7):1288-1302, (2008).
Menin, L., Perchuc, A., Favreau, P., Perret, F., Michalet, S., Schöni, R., Wilmer, M. and Stöcklin R.
Molecular characterisation of endogenous snake venom metalloproteinase inhibitors.
Biochem Biophys Res Commun. 365(4):650-656, (2008).
Wagstaff, S.C., Favreau, P., Cheneval, O., Laing, G.D., Wilkinson, M.C., Miller, R.L., Stöcklin, R. and Harrison R.A.
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2007
The venom of the snake genus Atheris contains a new class of peptides with clusters of histidine and glycine residues.
Rapid Commun. Mass Spectrom. 21:406-412, (2007).
Favreau, P., Cheneval, O., Menin, L., Michalet, S., Gaertner, H., Principaud, F., Thai, R., Ménez, A., Bule P. an Stöcklin, R.
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2006
Hemorphin and hemorphin-like peptides isolated from dog pancreas and sheep brain are able to potentiate bradykinin activity in vivo.
Peptides 27(11):2957-2966, (2006).
Ianzer, D., Konno, K., Xavier, C.H., Stöcklin, R., Santos, R.A., de Camargo, A.C. and Pimenta D.C.
Peptidomics and proteomics studies of transformed lymphocytes from patients mutated for the eukaryotic initiation factor 2B.
J. Chromatogr. B 840(1):20-28, (2006).
Fogli, A., Malinverni, C., Thadikkaran, L., Combes, P., Perret, F., Crettaz, D., Tissot, J.-D., Boespflug-Tanguy, O., Stöcklin, R. and Bulet, P.
Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen.
Toxicon 47(6):676-87, (2006).
Favreau, P., Menin, L., Michalet, S., Perret, F., Cheneval, O., Stöcklin, M., Bulet, P. and Stöcklin, R.
'Venomics' or: The venomous systems genome project.
Editorial. Toxicon 47(3):255-259, (2006).
Ménez, A., Stöcklin, R. and Mebs, D.
Characterization of a defensin from the oyster Crassostrea gigas. Recombinant production, folding, solution structure, antimicrobial activities, and gene expression.
J. Biol Chem. 281(1):313-23, (2006)
Gueguen Y, Herpin A, Aumelas A, Garnier J, Fievet J, Escoubas JM, Bulet P, Gonzalez M, Lelong C, Favrel P, Bachère E.
PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature.
Dev Comp Immunol. 30(3):283-8, (2006)
Gueguen Y, Garnier J, Robert L, Lefranc MP, Mougenot I, de Lorgeril J, Janech M, Gross PS, Warr GW, Cuthbertson B, Barracco MA, Bulet P, Aumelas A, Yang Y, Bo D, Xiang J, Tassanakajon A, Piquemal D and Bachère E.
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2005
Report of the round table discussion organised by the Swiss Proteomics Society (SPS), Bern, 8th December 2004.
Proteomics. 5(12):3017-8, (2005 Aug).
Noukakis D, Gadola S, Stöcklin R.
The potential of Bothrops moojeni venom in the field of hemostasis. Established use and new insights.
Pathophysiol. Haemost. Thromb. 34(4-5):241-5, (2005).
Perchuc, A.M., Menin, L., Stöcklin, R., Bühler, B. and Schöni, R.
A structural study of model peptides derived from HIV-1 integrase central domain.
Rapid Commun. Mass Spectrom. 19(8):2539-2548, (2005).
Maroun, R.G., Zargarian, L., Stöcklin, R., Troalen, F., Jankowski, C.K. and Fermandjian, S.
Proteomics for health.
Editorial: proteomics 8/2005. Proteomics 5(12):3007-09, (2005).
Palagi, P., Sanchez, J.C. and Stöcklin, R.
Protein mapping of the salivary complex from a hematophagous leech.
OMICS 9(2):194-208, (2005).
Ricci-Silva, M.E., Konno, K., Faria, F., Radis-Baptista, G., Fontes, W., Stöcklin, R., Michalet, S., Yamane, T. and Chudzinski-Tavassi, A.M.
Report of the round table discussion organised by the Swiss Proteomics Society (SPS), Bern, 8th December 2004.
Proteomics. 5(12):3017-8, (2005).
Noukakis, D., Gadola, S. and Stöcklin, R.
Insect antimicrobial peptides: structure, properties and gene regulation.
Protein and Peptide Letters 12:3-11, (2005).
Bulet, P. and Stöcklin, R.
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2004
Quantify this! Report on a round table discussion on quantitative mass spectrometry in proteomics.
Proteomics. 4(8):2211-5, (2004 Aug).
Quadroni M, Ducret A, Stöcklin R.
Long-sarafotoxins: structural and functional characterization of a new family of endothelin-like peptides
Peptides 25(8):1243-51, (2004).
Hayashi, M.A.F., Ligny-Lemaire, C., Wollberg, Z., Wery, M., Galat, A., Ogawa, T., Muller, B.H., Lam Thanh, H., Doljansky, Y, Bdolah, A., Stöcklin, R. and Ducancel, F.
Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography.
Peptides, 25(7):1085-92, (2004)
Ianzer, D., Konno, K., Marques-Porto, R., Vieira Portaro, F.C., Stöcklin, R., Martins de Camargo, A.C. and Pimenta, D.C.
Anti-microbial peptides: from invertebrates to vertebrates.
Immunol Rev., 198:169-84, (2004)
Bulet, P., Stöcklin, R. and Menin, L.
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2003
Proteomics application exercise of the Swiss Proteomics Society: report of the SPS'02 session.
Proteomics. 3(8):1562-6, (2003 Aug).
Binz PA, Abdi F, Affolter M, Allard L, Barblan J, Bhardwaj S, Bienvenut WV, Bulet P, Burgess J, Carrette O, Corthals G, Delalande F, Diemer H, Favreau P, Giuliano E, Gueguen Y, Guillaume E, Hahner S, Man P, Michalet S, Neri D, Noukakis D, Palagi P, Paroutaud P, Carvalho Pimenta D, Quadroni M, Resemann A, Richert S, Rybak J, Sanchez JC, Scherl A, Scheurer S, Schweiger Hufnagel U, Siethoff C, Suckau D, van Dorsselaer A, Wagner Redeker W, Walter N, Stöcklin R.
Profiling and in vivo quantification of proteins by high resolution tandem mass spectrometry: the example of goserelin, an analogue of LHRH.
Clin. Chem. Lab. Med., 41(12):1589-98, (2003)
Michalet, S., Favreau, P. and Stöcklin, R.
A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels.
Toxicon, 42(1):43-52, (2003)
Kauferstein, S., Huys, I., Lamthanh, H., Stöcklin, R., Sotto, P., Ménez, A., Tytgat, J. and Mebs, D.
Analysis of the metal-binding selectivity of the metallochaperone CopZ from Enterococcus hirae by electrospray ionization mass spectrometry.
Rapid Commun Mass Spectrom., 17(16):1889-96, (2003).
Urvoas, A., Amekraz, B., Moulin, C., Le Clainche, L., Stöcklin, R. and Moutiez, M.
Genetic and Ecological Correlates of Intraspecific Variation in Pitviper Venom Composition Detected Using Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) and Isoelectric Focusing.
J. Mol. Evol. 56(3):317-29, (2003)
Creer, S., Malhotra, A., Thorpe, R.S., Stöcklin, R., Favreau, P. and Chou, W.H.
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2002
Proteomics of venom peptides.
In : Perspectives in molecular toxinology (Ménez, A. Ed.), John Wiley & Sons Ltd, Chichester, UK. pp.107-123, (2002)
Stöcklin, R. and Favreau, P.
Challenges in mass spectrometry.
Proteomics. Jul;2(7):825-7, (2002).
Stöcklin R, Binz PA.
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2001
Venoms proteomics: Novel approaches for drug discovery.
In: Proceeding of the Swiss Proteomics Society, “2001 Congress Functional Proteomics” (Palagi, P., Sanchez, J.-C. and Stöcklin, R. Eds), FontisMedia S.A., Lausanne, Switzerland. Vol. 1, pp. 29-32, (2001).
Favreau, P., Michalet, S. and Stöcklin, R.
Moving pieces in a proteomic puzzle: mass fingerprinting of toxic fractions from the venom of Tityus serrulatus (SCORPIONES, Buthidae).
Rapid Commun. Mass Spectrom. 15(17), 1562-1572, (2001)
Pimenta, A.M.C., Stöcklin, R., Favreau, P., Bougis, P.E. and Martin-Eauclaire, M.-F.
A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity.
Biochemistry, 40(48):14567-75, (2001).
Favreau P., Gilles N., Lamthanh H., Bournaud R., Shimahara T., Bouet F., Laboute P., Letourneux Y., Menez A., Molgo J. and Le Gall F.
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2000
Positive and negative labelling of human proinsulin, insulin and C-peptide with stable isotopes : new tools for metabolic and pharmacokinetic studies.
In: Protein and peptide analysis: advances in the use of mass spectrometry, “Methods in Molecular Biology”(Chapman, J. Ed.), Humana Press, Totowa, NJ, USA. Vol. 146, pp. 293-315, (2000).
Stöcklin, R., Arrighi, J.-F., Hoang-Van, K., Vu, L., Cerini, F., Gilles, N., Genet, R., Markussen, J., Offord, R.E. and Rose, K.
Identification of snake species by toxin mass fingerprinting of their venoms.
In : Protein and peptide analysis : advances in the use of mass spectrometry, “Methods in Molecular Biology” (Chapman, J. Ed.), Humana Press, Totowa, NJ, USA. Vol. 146, pp. 317-335, (2000).
Stöcklin R., Mebs D., Boulain J.-C., Panchaud P.-A., Virelizier, H. and Gillard-Factor C.
Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.
J. Biol. Chem., 275, 33464-33470, (2000).
Silva P.I. Jr, Daffre S. and Bulet P.
Relative spatial position of a snake neurotoxin and the reduced disulfide bond alpha (Cys192-Cys193) at the alpha gamma interface of the nicotinic acetylcholine receptor.
J Biol Chem., 275(33):25608-15, (2000).
Michalet S., Teixeira F., Gilquin B., Mourier G., Servent D., Drevet P., Binder P., Tzartos S., Menez A., Kessler P.
Insect peptides with improved protease-resistance protect mice against bacterial infection.
Protein Sci., 9, 742-749, (2000).
Otvos L. Jr, Bokonyi K., Varga I., Otvos B.I., Hoffmann R., Ertl H.C., Wade J.D., McManus A.M., Craik D.J. and Bulet P.
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1999
Venomous snakes of the world. VENOMS – The ultimate database on venomous animals.
Version 1.1: CD-ROM 1. Edited by Atheris Laboratories, Geneva, Switzerland, (1999).
Stöcklin, R. and Cretton, G.
Antimicrobial peptides in insects: structure and function.
Developmental and Comparative Immunology; 23, 329-344, (1999)
Bulet P., Hetru C., Dimarcq J.-L. and Hoffmann D.
A comparison of MALDI-TOF-MS and LC-ES-MS methods for the analysis of crude tarantula venoms in the Pterinochilus group.
Rapid Commun. Mass Spectrom., 13, 1861-1868, (1999).
Escoubas, P., Chamot-Rooke, J., Stöcklin, R., Whiteley, B.J., Genet, R. and Nakajima, T.
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... and a few oldies...
Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study.
Proc. Natl. Acad. Sci. USA, 95, 11342-11347, (1998).
Uttenweiler-Joseph S., Moniatte M., Lagueux M., Van Dorsselaer A., Hoffmann J.A. and Bulet P.
A stable isotope dilution assay for in vivo determination of insulin levels in man by mass spectrometry.
Diabetes 46, 44-50, (1997).
Stöcklin, R., Vu, L., Vadas, L., Cerini, F., Kippen, A.D., Offord,
R.E. and Rose, K.
Characterization of a potassium channel toxin from the sea anemone Stichodactyla helianthus.
Toxicon 33, 603-613, (1995)
Castañeda, O., Sotolongo, V., Amor, A.M., Stöcklin, R., Harvey, A.L., Engström, A., Wernstedt, C. and Karlsson, E.
The semisynthesis of octadeutero-PheB1-octadeutero-ValB2-porcine insulin and its characterization by mass spectrometry.
Protein engng 7, 285-289, (1994)
Stöcklin, R., Rose, K., Green, B.N., and Offord, R.E.
Snake proteins and nucleic acids.
Toxicon 31, 536-537, (1993)
Stöcklin, R., Golay, P., and Bairoch, A.
Facile identification by electrospray mass spectrometry of the insulin fragment A14-21-B17-30 produced by insulin proteinase.
Rapid Commun. Mass Spectrom. 7(11):1048-50, (1993)
Vu, L., Stöcklin, R., Rose, K. and Offord, R.E.
Upregulation of urokinase receptor expression on migrating endothelial cells.
J. Cell. Biol. 122, 673-684, (1993)
Pepper, M.S., Sappino, A.-P., Stöcklin, R., Montesano, R., Orci, L., and Vassalli, J.-D.
Azemiops - A worldwide database on venomous snakes.
In: Recent advances in toxinology research, volume 1, pp. 737-745. Edited by Gopalakrishnakone, P. and Tan, C.K., Singapore, Venom and Toxin Research Group, (1992).
Golay, P. and Stöcklin, R.
Reaction mechanism of trypsin-catalysed semisynthesis of human insulin studied by fast atom bombardment mass spectrometry.
Protein engng 4, 409-412, (1991)
Rose, K., Stöcklin, R., Savoy, L.-A., Regamey, P.-O., Offord, R.E., Vuagnat, P., and Markussen, J.
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