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Tuesday, April 18 - Welcome & Opening |
| 09:00 - 14:00 |
Exhibition set-up |
| 14:00 - 17:00 |
Opening of the registration desk |
| 15:30 - 16:30 |
WELCOME RECEPTION |
| SESSION I - Natural Peptides To Drugs |
| 16:30 - 16:45 |
Opening ceremony & Welcome notes |
| 16:45 - 17:30 |
Opening Lecture: Prof. Geoffrey W. TREGEAR Relaxin: the journey from discovery to clinical trials Howard Florey Institute, Australia |
| 17:30 - 19:10 |
Oral presentations |
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Prof. Robin Offord
Using high technology to find simple solutions for developing countries The Mintaka Foundation for Medical Research |
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Dr Maria Luisa Mangoni Short host-defence peptides from frog skin
Universitŕ La Sapienza, Rome, Italy |
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Dr David Deperthes
Substrate peptides for the development of protease inhibitors
Med Discovery SA, Geneva, Switzerland |
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Prof. Sylvie Rebuffat
Siderophore-microcins, antimicrobial peptides with potent activity against Enterobacteriaceae: structure, biosynthesis and recognition National Museum of Natural History, Paris, France |
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Dr Reto Stöcklin Mass spectrometry mapping of Atheris snake venom reveals a new family of peptides Atheris Laboratories, Geneva, Switzerland |
| 19:10 - 19:30 |
Hot-spot & lift presentations |
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Dr Karine Puget
New natural peptides for GPCR de-orphanization Genepep SA, Clapiers, France |
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Dr Astrid Weiss
Survivin – an inhibitor of apoptosis as a target for peptide based therapy of human breast cancer Georg Speyer Haus, Biomedical Research, Frankfurt am Main, Germany |
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Dr Anne Fogli
Peptidomics and proteomics studies of transformed lymphocytes from patients with leukodystrophy Atheris Laboratories, Geneva, Switzerland |
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Prof. André Ménez "Venomics" or : The venomous systems genome project CEA-Saclay, France |
| 20:15 - |
SWISS-EVENT DINNER |
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Wednesday, April 19 - From Natural Peptides |
| SESSION II - Genomics & Proteomics |
| 8:15 - 9:00 |
Invited Lecture: Dr Michael J. BROWNSTEIN Venomics: A Primer J. Craig Venter Institute, Rockville, USA |
| 9:00 - 10:00 |
Oral presentations |
| !!! NEW !!! |
Dr Shubh Sharma From Peptides to Small Molecule Drug Candidates – Development of Melanotropin Receptor Ligands for the Treatment of Obesity Palatin Technologies, Inc., Cranbury, USA |
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Mrs Anna Perchuc & Dr Laure Menin
Structural and heparin-binding properties of two Bothrops moojeni phospholipases A2 and their derived C-terminal synthetic fragments Pentapharm Ltd., Basel & Atheris Laboratories, Geneva, Switzerland |
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Prof. Ponnampalam Gopalakrishnakone
Dual inhibitors of sPLA2 and MMP-1: A new potential therapeutic option for treatment of inflammation National University of Singapore, Faculty of Medicine, Singapore |
| 10:00 - 10:30 |
COFFEE BREAK |
| SESSION III - Drug Discovery |
| 10:30 - 11:15 |
Invited Lecture: Prof. Alan HARVEY Protease-activated receptors as targets for anti-inflammatory drug discovery Strathclyde Institute for Drug Research, UK |
| 11:15 - 11:50 |
Hot-spot presentations |
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Dr Inna Radzishevsky Structure-activity relationships in a novel class od antimicrobial pseudopeptides Technion, Haifa, Israel |
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Prof. Paul Alewood
Selenotoxins: A new chemical class of peptide drugs University of Queensland, Australia |
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Dr Csaba Tömböly Design and synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-one containing endomorphin-2 mimetics Institute of Biochemistry, Biological Research Center, Szeged, Hungary |
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Dr Peter Cassidy The use of diastereomeric variation to produce peptide turn mimetics with low nanomolar affinity Mimetica Pty, Ltd, Brisbane, Australia |
| !!! NEW !!! |
Prof. Alan Harvey The International Society on Toxinology 2006 World Congress in Glasgow Strathclyde Institute for Drug Research, UK |
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Title and speaker to be advised |
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12:30 - 16:30
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JOURNEY BY TRAIN TO GORNERGRAT MOUNTAIN (3'135 m) LUNCH BREAK OPEN AIR ACTIVITIES |
| SESSION IV - Lead identification |
| 17:15 - 18:00 |
Invited Lecture: Dr Per Holse MYGIND Plectasin, beyond nature – improving the natural peptide and developing a process for bioproduction Novozymes A/S, Denmark |
| 18:00 - 18:55 |
Oral presentations |
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Prof. David Craik Structure and self association of the antiviral theta defensin retrocyclin-2 University of Queensland, Brisbane, Australia |
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Dr Irmgard Irminger-Finger BARD1, a promising target for selective cancer cell killing University Hospitals Geneva HUG, Geneva Switzerland |
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Dr Nicolas Gilles
A GPCR binding toxin as a new drug candidate against lower urinary track symptoms CEA-Saclay, France |
| 18:55 - 19:15 |
COFFEE BREAK |
| SESSION V - Lead optimisation |
| 19:15 - 20:00 |
Invited Lecture: Dr Alain BECK Peptides as tools and drugs for immunotherapies Centre d'Immunlogie Pierre Fabre, Saint-Julien, France |
| 20:00 - 20:40 |
Oral presentations |
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Dr Jan Vrijbloed
POL7001, a novel and potent pseudomonal antibiotic protects mice in a septicemia model Polyphor, Allschwil, Switzerland |
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Dr Paul R. Hansen
Identification of antibacterial lysine-peptoid hybrids using a mixture-based combinatorial library
Royal Veterinary and Agricultural University, Copenhagen, Denmark |
| 20:40 - |
FREE EVENING |
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Thursday, April 20 - Through Development |
| SESSION VI - Drug design & Modelling |
| 8:30 - 9:15 |
Invited Lecture: Dr John P. MAYER Melanocortin peptides for obesity Eli Lilly and Co., Indianapolis, USA |
| 9:15 - 10:35 |
Oral presentations |
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Dr Amram Mor
Novel antimicrobial peptidomimetics composed of acylated charged amino acids Technion, Haifa, Israel |
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Dr Emanuel Escher
Molecular structures, ligand binding and activation mechanisms for peptidergic G-protein coupled receptors for rational drug design Faculté de Médecine et Sciences de la Santé, Sherbrooke, Canada |
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Dr Marie Skovgaard
Using evolutionary information to understand the structure-sequence relationship of GLP-1 agonists Novo Nordisk A/S, Maaloev, Denmark |
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Prof. Anne Ulrich
Structure and function of membrane-active peptides by solid state NMR
University of Karlsruhe and Forschungszentrum Karlsruhe, Germany |
| 10:35 - 11:00 |
COFFEE BREAK & POSTERS |
| SESSION VII - Production & Manufacturing |
| 11:00 - 11:45 |
Invited Lecture: Prof. Stephen B. H. KENT Industrial chemical protein synthesis: what will it take to make it happen? University of Chicago, USA |
| 11:45 - 12:45 |
Oral presentations |
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Dr Jon Nissen-Meyer
Structure and mode of action of the membrane-permeabilizing antimicrobial peptide pheromone plataricin A University of Oslo, Norway |
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Dr Luisa Bracci Protease-resistant branched peptides as tumor targeting agents University of Siena, Italy |
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Prof. André Ménez The same small three-fingered fold for human uPAR and toxins CEA-Saclay, France |
| 12:45 - 14:00 |
LUNCH BREAK |
| 14:00 - 17:00 |
OPTIONAL ACTIVITIES & NETWORKING SESSIONS |
| SESSION VIII - Formulation & Drug Delivery |
| 17:00 - 17:45 |
Invited Lecture: Dr Jennifer RIGGS-SAUTHIER The art of PEGylation: advancing peptide drugs into the future Nektar Therapeutics, Hunstville, USA |
| 17:45 - 19:05 |
Oral presentations |
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Dr Corina Borghouts-Heinz
Peptides as inhibitors of signalling components in cancer cells Georg Speyer Haus, Biomedical Research, Frankfurt am Main, Germany |
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Dr Michel Geffard
Anti-bacterial activity of fatty acids linked on a polypeptide Laboratory PIOM-EPHE, Pessac, France |
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Dr Jorg Ronco
Evaluation of the E‑patch® technology for transcutaneous peptide delivery. MA320 model DBV Technologies, Boulogne Billancourt, France |
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Prof. Keith Rose
Multivalency – a way to enhance binding avidities and bioactivity – application to EPO Department of Structural Biology and Bioinformatics, University of Geneva, Switzerland |
| 20:00 - |
GALA DINNER |
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Friday, April 21 - To Clinics |
| SESSION IX - Development & Clinical Trials |
| 8:30 - 9:15 |
Invited Lecture: Dr Patrick GARROUSTE Debio Group, Switzerland Key issues in the development of peptide drugs |
| 9:15 - 10:35 |
Oral presentations |
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Dr Chandra Panchal
Evaluation of a prostate secretory protein94-derived synthetic peptide PCK3145 in patients with castrate metastatic prostate cancer: Inhibition of VEGF signaling, MMP-9 secretion and CD44-mediated MMP-9 cell surface binding Ambrilia Biopharma, Verdun, Quebec, Canada |
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Dr Thomas Dix
Non-natural arginine and lysine analogs in peptide drug development Argolyn Bioscience, Inc., North Charleston, USA |
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Dr Markwin Velders
Antimicrobial peptides; how good can they get ? AM-Pharma, Bunnik, Netherlands |
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Prof. Paul Alewood
Drug Discovery - where are we now and where are we going? University of Queensland, Australia |
| 10:35 - 11:00 |
COFFEE BREAK |
| SESSION X - Route to Clinic |
| 11:00 - 11:45 |
Closing Lecture: Dr George MILJANICH PRIALTŇ (ziconotide intrathecal infusion): a conopeptide for treating severe chronic pain Airmid LLC, USA |
| 11:45 - 13:00 |
Roundtable: Peptides Drugs : Mistakes to Avoid ! Four presentations by experts in intellectual property, funding, production & regulatory. Followed by an open debate. |
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Dr Emmanuel Jelsch Katzarov S.A., Switzerland |
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Dr Peter Hoffmann Genzyme Pharmaceuticals, USA |
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Dr Michel-Alain Mollard SPEF Venture, France |
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Dr Daniel Bourgin Lonza, Switzerland |
| 13:00 - 13:10 |
Closing Notes |
| 13:10 - |
FAREWELL COCKTAIL / LUNCHEON |
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